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Research Monitors Exhaled HCN Profiles in Single Breath

In a recent study, a flow-assisted photoionization mass spectrometry method was developed for profiling hydrogen cyanide (HCN) in exhaled breath. Sensitivity and response speed of direct HCN measurements in exhaled breath at high humidity presented challenges. To improve the sensitivity and time resolution, the researchers proposed to use helium shield gas, which reduced the effect of high humidity on ionization, improved ion transport efficiency and enhanced HCN detection sensitivity. The method achieved a limit of detection of 0.3 ppbv and a resolution time of 0.5 s, and demonstrated good resistance to interference and high accuracy in HCN quantification, making it a potential application for the detection of Pseudomonas aeruginosa (PA) infection in cystic fibrosis (CF) patients.

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